Released on = July 26, 2007, 8:37 am

Press Release Author = AnaSpec Inc.

Industry = Biotech

Press Release Summary = AnaSpec has introduced acetylated, mono-methylated,
di-methylated and tri-methylated Lysine for the synthesis of histone peptides. The
use of these building blocks, although not limited to making synthetic histone
peptides, provides additional tools for researchers to help unravel the "histone
code."

Press Release Body = July 23, 2007 - San Jose, CA
AnaSpec has introduced acetylated, mono-methylated, di-methylated and tri-methylated
Lysine for the synthesis of histone peptides. The use of these building blocks,
although not limited to making synthetic histone peptides, provides additional tools
for researchers to help unravel the "histone code."5
The lysine-rich amino terminal tail of the core histones undergo posttranslational
modifications such as acetylation and methylation.1-2 Addition of acetyl group or 1
to 3 methyl groups occur at position specific lysines.3-4 These modifications, as
well as phosphorylation of serine residues and others, serve to differentially
regulate chromatin activity.5
Acetylated Lysines
Fmoc-Lys(Ac)-OH
Boc-Lys(Ac)-OH

Methylated Lysines
Fmoc-Lys(Me, Boc)-OH
Fmoc-Nε,ε-dimethyl-L-lysine hydrochloride salt
Boc-Nε,ε-dimethyl-L-lysine hydrochloride salt
Fmoc-Lys(Me)3-OH chloride

Phosphorylated Serines
Fmoc-Ser[PO(OBzl)-OH]-OH
Fmoc-D-Ser[PO(OBzl)-OH]-OH

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Web Site = http://

Contact Details = 2149 O\'Toole Ave.
San Jose, CA 95131
1-408-452-5055
ping@anaspec.com